https://mayalucia.dev/tags/connectivity/ Recent content in Connectivity on MayaLucIA Hugo -- 0.156.0 en-us Wed, 25 Feb 2026 12:00:00 +0100 https://mayalucia.dev/domains/bravli/connectivity/ Wed, 25 Feb 2026 12:00:00 +0100 https://mayalucia.dev/domains/bravli/connectivity/ <p>The FlyWire connectome provides the complete synaptic wiring diagram: every connection between every neuron, annotated with neurotransmitter type and synapse count. This lesson turns that raw edge list into analysable connectivity matrices and pathway maps.</p> <h2 id="lesson-08--connectivity">Lesson 08 &mdash; Connectivity</h2> <p>Starting from ~50 million synaptic connections:</p> <ol> <li><strong>Edge list loading</strong> &mdash; parsing the FlyWire synapse table</li> <li><strong>Neurotransmitter assignment</strong> &mdash; each synapse inherits its presynaptic neuron&rsquo;s NT identity (ACh, GABA, Glu, 5-HT, DA, OA)</li> <li><strong>Neuropil connectivity matrices</strong> &mdash; aggregating synapses by source/target neuropil to reveal the coarse wiring diagram</li> <li><strong>Pathway analysis</strong> &mdash; tracing multi-hop paths between regions</li> <li><strong>Motif analysis</strong> &mdash; identifying recurring circuit motifs (reciprocal, convergent, divergent)</li> </ol> <p>The connectivity matrix is the skeleton on which all simulation and analysis hangs. Get this right, and the dynamics emerge from the wiring.</p>