https://mayalucia.dev/tags/digital-twins/ Recent content in Digital-Twins on MayaLucIA Hugo -- 0.156.0 en-us Mon, 02 Mar 2026 22:00:00 +0100 https://mayalucia.dev/papers/neuroai-validation/ Mon, 02 Mar 2026 22:00:00 +0100 https://mayalucia.dev/papers/neuroai-validation/ <h2 id="from-biophysical-to-functional-two-generations-of-neural-digital-twins">From Biophysical to Functional: Two Generations of Neural Digital Twins</h2> <p>The first generation of neural digital twins was biophysical. The Blue Brain Project (EPFL, 2005&ndash;2024) reconstructed cortical microcircuits at morphological and biophysical detail &mdash; individual neurons with reconstructed dendrites, calibrated ion channels, stochastic synapses. Validation meant checking 40+ experimental constraints: layer-specific firing rates, connection probabilities, orientation selectivity indices. The framework that systematized this validation was DMT (Data, Models, Tests), developed 2017&ndash;2024 and published in eLife.</p>